Breakthrough In The Development Of A Vaccine Against Alzheimer'sIsrael - Dr Mononego University in Beer Shiva has demonstrated the ability to test and measure specific immune responses in mice carrying human genes: he hopes to anticipate the immune response of patients with AD.
Amyloid plaques accumulate in the brains of Alzheimer patients. Dr. Monsonego has determined that the introduction of beta-amyloid peptide responsible for the formation of plaques in the brain, triggering a natural immune response. The magnitude of this response depends on certain immune system genes, very different to different people.
The research team has a humanized mouse model suffering from Alzheimer's disease with a specific gene present in approximately 30% of the study group. By stimulating an immune response to the peptide on these humanized mice, the researchers found a significantly reduced inflammatory response. These results are identical in humans.
This discovery is a very promising track to creating a vaccine based on genetic background and to develop an approach to personalized immunotherapy. Further studies should now demonstrate the safety and efficacy of the humanized mouse model.
Amyloid plaques accumulate in the brains of Alzheimer patients. Dr. Monsonego has determined that the introduction of beta-amyloid peptide responsible for the formation of plaques in the brain, triggering a natural immune response. The magnitude of this response depends on certain immune system genes, very different to different people.
The research team has a humanized mouse model suffering from Alzheimer's disease with a specific gene present in approximately 30% of the study group. By stimulating an immune response to the peptide on these humanized mice, the researchers found a significantly reduced inflammatory response. These results are identical in humans.
This discovery is a very promising track to creating a vaccine based on genetic background and to develop an approach to personalized immunotherapy. Further studies should now demonstrate the safety and efficacy of the humanized mouse model.
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