BREAKTHROUGH IN THE DEVELOPMENT OF A VACCINE AGAINST ALZHEIMER'S

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Breakthrough In The Development Of A Vaccine Against Alzheimer's
Israel - Dr Mononego University in Beer Shiva has demonstrated the ability to test and measure specific immune responses in mice carrying human genes: he hopes to anticipate the immune response of patients with AD.

Amyloid plaques accumulate in the brains of Alzheimer patients. Dr. Monsonego has determined that the introduction of beta-amyloid peptide responsible for the formation of plaques in the brain, triggering a natural immune response. The magnitude of this response depends on certain immune system genes, very different to different people.

The research team has a humanized mouse model suffering from Alzheimer's disease with a specific gene present in approximately 30% of the study group. By stimulating an immune response to the peptide on these humanized mice, the researchers found a significantly reduced inflammatory response. These results are identical in humans.

This discovery is a very promising track to creating a vaccine based on genetic background and to develop an approach to personalized immunotherapy. Further studies should now demonstrate the safety and efficacy of the humanized mouse model.

2 comments:

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