IDENTIFICATION OF THE GENETIC CAUSE OF MOST COMMON FORM OF BREAST CANCER

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Identification Of The Genetic Cause Of Most Common Form Of Breast Cancer
The discovery of tumor suppressor genes has been the main key to having an understanding of the molecular and cellular mechanisms leading to uncontrolled proliferation of cells, a mechanism of cancer.

Researchers at the University of North Carolina School of Medicine have found that defects in a gene called p18, can lead to cancer. This discovery, combined with new laboratory techniques, will help scientists to identify and explore new treatments for a tumor type representing 70 and 80% of all breast cancers. The research results were published in the medical journal Cancer Cell May 2009.

Defects in the gene p18 were observed in different types of human cancers. According to lead author, Dr. Yue Xiong, Ph.D., professor of biochemistry and biophysics, when this gene is not expressed cells continue to grow, divide until they become cancer.

When studying this author and his collaborators have shown that decreased expression of p18 gene is strongly correlated with the development of a common type of breast tumors. The formation mechanism of this type of tumor is very different from other forms of breast cancer. Having understood the mechanism and having a laboratory animal genetically modified to conduct experiments, the authors propose to examine specific treatments against these tumors.
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Source: Eurekalert
University of North Carolina School of Medicine

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